The Medical News

1. HPV infections continue after age 27, so who is still at risk?

   HPV infections in women aged 27+ highlight the need for updated vaccination policies, emphasizing ongoing risk and the importance of preventive healthcare.

2. Mailed DNA-based test for colorectal cancer screening

   The use of mailed FIT-DNA kits in community health centers significantly increases colorectal cancer screening, though follow-up colonoscopy rates remain low.

3. Baby teeth show when metal exposure may affect brain development

   The study identifies critical windows of metal exposure via baby teeth, revealing impacts on brain development and behavior in children and adolescents.

4. Sapio Sciences brings Claude Cowork to the lab

   Sapio Sciences, the AI lab informatics company, today announced that Claude Cowork, Anthropic's agentic AI assistant, is now integrated with the Sapio Platform via Sapio Elain, the AI co-scientist.

5. DeNovix launches Squid™ Full Range Pipette: A single device covering 1 – 1000 µL

   DeNovix Inc. has introduced a new product to their innovative collection of life science devices—the Squid™ Full Range Pipette.

6. From killers to strategists: CAR T cells enter their multifunctional era

   A review of 1,801 registered CAR T clinical trials shows that multifunctional designs now account for 533 trials and 33% of new CAR T products submitted for clinical testing in 2025. The field is shifting toward multitargeted, safety-controlled, cytokine-secreting, and checkpoint-modulating CAR T cells, but manufacturing, regulation, and limited clinical outcome data remain key barriers.

7. Single-cell sequencing reveals why some CAR-T therapies succeed while others fail

   Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.

8. Metabolic rewiring could help CAR-T cells fight solid tumors

   This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.