The Medical News

1. Study reveals how DNA misfolding causes congenital heart disease

   Congenital heart disease is the most common birth defect, affecting approximately 1 in 100 babies born each year. One of the many causes for this disorder is having only one functional copy of the gene TBX5, instead of two healthy copies, inherited from parents.

2. New model holds promise as a non-invasive, low-cost tool for MAFLD screening

   Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a predominant cause of chronic liver disease, underscoring the demand for accessible, non-invasive diagnostic tools.

3. Researchers link genome folding to gene activity and brain tissue organization in Alzheimer's

   Researchers from Carnegie Mellon University's School of Computer Science, the University of Pittsburgh School of Medicine and the University of Washington shed new light on Alzheimer's disease that could point to new directions for treatment.

4. Study reveals dynamic remodeling of genome architecture during brain aging

   Researchers have discovered that the human brain undergoes widespread age-related changes in genome regulation beginning in midlife that may help explain why aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer's.

5. MEK inhibition could limit T cell exhaustion and give a boost to immunotherapy

   A major pillar of cancer immunotherapy involves stimulating T cells, the specialized killers of the immune system, to attack tumors.

6. Study reveals high prevalence of post-pandemic fatigue and sleep disturbances

   Disrupted sleep and anxiety may be an ongoing issue for many people after the pandemic, whether due to COVID-19 directly or to the stress and anxiety caused by the global pandemic, and may contribute to the fatigue commonly reported by people with Post-COVID-19 Syndrome (PCS, or 'long COVID').

7. Researchers develop artery-on-a-chip platform to predict stroke risk

   Predicting an individual's risk of ischemic stroke is difficult because thrombosis embolization-the process of a blood clot detaching from the area where it formed and traveling to and then sticking in another blood vessel-is based on factors that are unique to each person.

8. Mass-producible immune cells fight solid human tumors in mice

   Off-the-shelf and mass-producible immune cells fight solid human tumors engrafted into mice. The Kobe University development is a significant contribution towards faster and cheaper cancer immunotherapy.