The Medical News

1. Orexo and SVF Vaccines collaborate to explore AmorphOX® formulation of LNP-mRNA vaccines

   Orexo AB and SVF Vaccines AB today announced a research collaboration to investigate whether Orexo’s proprietary powder-based drug delivery technology, AmorphOX®, can be used to develop stable powder-based formulations of lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) vaccines.

2. Richmond Pharmacology highlights encouraging first-in-human results for Regeneron's investigational RNAi therapy in MASLD

   Richmond Pharmacology, a specialist early-phase clinical research organization, has announced encouraging results from a first-in-human clinical trial evaluating CIDEBsiRNA, an investigational RNA interference (RNAi) therapy developed by Regeneron Pharmaceuticals, Inc.

3. Researchers associate personality shifts with frontotemporal dementia functional decline

   Frontotemporal dementia often results in early changes in personality or behavior before changes in cognitive skills.

4. Ephrin-B1 phosphorylation disrupts nephrin complexes in nephrotic syndrome pathogenesis

   A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University identified a novel Ca2+-independent pathogenic mechanism of nephrotic syndrome.

5. Beyond food: Bran-based gels show potential for targeted drug delivery

   When it comes to colon health, the benefits of wheat and rye bran in wholegrain foods are well-known. Now researchers in Sweden have shown how these fibers may have a therapeutic use, too.

6. Adelaide researchers investigate optimal exercise and education for neck pain

   Whether you hunch over a computer or spend hours scrolling on your phone, everyday habits can be a real pain in the neck. But when that pain persists, it can take a serious toll on everyday life, affecting everything from work and sleep to physical activity and wellbeing.

7. Study decodes combinatorial p53 modification networks

   A recent review highlights that p53 activity is orchestrated by a combinatorial network of post-translational modifications (PTMs), in which writers, erasers and reader proteins dynamically shape protein stability, DNA binding, subcellular localization, co-regulator assembly and transcriptional output.

8. Meta analysis quantifies annual Alzheimer's incidence in type 2 diabetes

   A Curtin University-led review has revealed type 2 diabetes significantly raises risk of developing Alzheimer's disease.